Home Advanced Medicine Mustang Bio and St. Jude Children’s Research Hospital announce MB-107 lentiviral gene therapy for X-linked Severe Combined Immunodeficiency (XSCID) granted regenerative medicine advanced therapy (RMAT) designation from FDA – Yahoo Finance
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Mustang Bio and St. Jude Children’s Research Hospital announce MB-107 lentiviral gene therapy for X-linked Severe Combined Immunodeficiency (XSCID) granted regenerative medicine advanced therapy (RMAT) designation from FDA – Yahoo Finance

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<p class="canvas-atom canvas-text Mb(1.0em) Mb(0)–sm Mt(0.8em)–sm" type="text" content="RMAT designation follows positive Phase 1/2 clinical data published in the New England Journal of Medicine” data-reactid=”11″>RMAT designation follows positive Phase 1/2 clinical data published in the New England Journal of Medicine

<p class="canvas-atom canvas-text Mb(1.0em) Mb(0)–sm Mt(0.8em)–sm" type="text" content="&nbsp;Designation to facilitate expedited development and review of MB-107 for XSCID” data-reactid=”12″> Designation to facilitate expedited development and review of MB-107 for XSCID

<p class="canvas-atom canvas-text Mb(1.0em) Mb(0)–sm Mt(0.8em)–sm" type="text" content="NEW YORK and MEMPHIS, Tenn., Aug. 22, 2019 (GLOBE NEWSWIRE) — Mustang Bio, Inc. (MBIO) and St. Jude Children’s Research Hospital have announced that MB-107, a lentiviral gene therapy for the treatment of X-linked severe combined immunodeficiency, also known as bubble boy disease, has been granted the Regenerative Medicine Advanced Therapy (RMAT) designation by the U.S. Food and Drug Administration (FDA).” data-reactid=”13″>NEW YORK and MEMPHIS, Tenn., Aug. 22, 2019 (GLOBE NEWSWIRE) — Mustang Bio, Inc. (MBIO) and St. Jude Children’s Research Hospital have announced that MB-107, a lentiviral gene therapy for the treatment of X-linked severe combined immunodeficiency, also known as bubble boy disease, has been granted the Regenerative Medicine Advanced Therapy (RMAT) designation by the U.S. Food and Drug Administration (FDA).

Mustang, a clinical-stage biopharmaceutical company focused on translating today’s medical breakthroughs in cell and gene therapies into potential cures for hematologic cancers, solid tumors and rare genetic diseases, and St. Jude, the nation’s leading hospital dedicated to understanding, treating and curing childhood cancer and other life-threatening diseases, established a partnership to continue development of the lentiviral gene therapy in August 2018.

<p class="canvas-atom canvas-text Mb(1.0em) Mb(0)–sm Mt(0.8em)–sm" type="text" content="Under the terms of the RMAT designation, the FDA will help facilitate the program’s expedited development and review and provide guidance on generating the evidence needed to support the approval of MB-107 for XSCID. RMAT designation was granted to MB-107 based on positive Phase 1/2 clinical data for infants with XSCID under the age of 2 (ClinicalTrials.gov Identifier: NCT01512888), which were published in the New England Journal of Medicine in April 2019.&nbsp;” data-reactid=”15″>Under the terms of the RMAT designation, the FDA will help facilitate the program’s expedited development and review and provide guidance on generating the evidence needed to support the approval of MB-107 for XSCID. RMAT designation was granted to MB-107 based on positive Phase 1/2 clinical data for infants with XSCID under the age of 2 (ClinicalTrials.gov Identifier: NCT01512888), which were published in the New England Journal of Medicine in April 2019. 

“We are very pleased that the FDA has granted RMAT designation to MB-107,” said Manuel Litchman, M.D., president and chief executive officer of Mustang. “This exciting milestone further validates the compelling data generated to date and affirms the potential of MB-107 to address a typically fatal condition with few effective treatment options. We look forward to working with the FDA and our partners at St. Jude to potentially expedite the development and approval of this critically needed treatment option. In particular, we are on track to accept the Investigational New Drug (IND) transfer from St. Jude to Mustang in the fourth quarter of this year.”

Drugs eligible for RMAT designation are those intended to treat, modify, reverse or cure a serious or life-threatening disease or condition, and that present preliminary clinical evidence indicating the drug has the potential to address unmet medical needs for such disease or condition. The FDA has determined that MB-107 for the treatment of XSCID meets the criteria for RMAT designation.

“Receiving RMAT designation by the FDA is an important step forward and should speed up the process of getting patients access to lentiviral gene therapy for XSCID,” said Stephen Gottschalk, M.D., chair of the St. Jude Department of Bone Marrow Transplantation and Cellular Therapy. “We are excited to continue our collaboration with Mustang Bio and our academic partners to advance this new, potentially life-saving treatment option toward FDA approval.”

RMAT designation provides regenerative medicine advanced therapy products with the same benefits to expedite the development and review of a marketing application that are available to drugs that receive Breakthrough Therapy Designation. These advantages include timely advice and interactive communications with FDA, as well as proactive and collaborative involvement by senior FDA managers and experienced review and regulatory health project management staff. A product designated as an RMAT also may be eligible for other FDA-expedited programs, such as Priority Review. The FDA also may conduct a rolling review of products in its expedited programs, reviewing portions of a marketing application before the complete application is submitted.

<p class="canvas-atom canvas-text Mb(1.0em) Mb(0)–sm Mt(0.8em)–sm" type="text" content="About X-linked Severe Combined Immunodeficiency (XSCID)
X-linked severe combined immunodeficiency is a rare genetic disorder that occurs in approximately 1 per 225,000 births. It is characterized by the absence or lack of function of key immune cells, resulting in a severely compromised immune system and death by 1 year of age if untreated. Patients with XSCID have no T cells or natural killer cells. Although their B cells are normal in number, they are not functional. As a result, XSCID patients are usually affected by severe bacterial, viral or fungal infections early in life and often present with interstitial lung disease, chronic diarrhea and failure to thrive.” data-reactid=”20″>About X-linked Severe Combined Immunodeficiency (XSCID)
X-linked severe combined immunodeficiency is a rare genetic disorder that occurs in approximately 1 per 225,000 births. It is characterized by the absence or lack of function of key immune cells, resulting in a severely compromised immune system and death by 1 year of age if untreated. Patients with XSCID have no T cells or natural killer cells. Although their B cells are normal in number, they are not functional. As a result, XSCID patients are usually affected by severe bacterial, viral or fungal infections early in life and often present with interstitial lung disease, chronic diarrhea and failure to thrive.

The specific genetic disorder that causes XSCID is a mutation in the gene coding for the common gamma chain (γc), a protein that is shared by the receptors for at least six interleukins. These interleukins and their receptors are critical for the development and differentiation of immune cells. The gene coding for γc is known as IL-2 receptor gamma, or IL2RG. Because IL2RG is located on the X-chromosome, XSCID is inherited in an X-linked recessive pattern, resulting in almost all patients being male.

<p class="canvas-atom canvas-text Mb(1.0em) Mb(0)–sm Mt(0.8em)–sm" type="text" content="About Mustang Bio
Mustang Bio, Inc. is a clinical-stage biopharmaceutical company focused on translating today’s medical breakthroughs in cell and gene therapies into potential cures for hematologic cancers, solid tumors and rare genetic diseases. Mustang aims to acquire rights to these technologies by licensing or otherwise acquiring an ownership interest, to fund research and development, and to out license or bring the technologies to market. Mustang has partnered with top medical institutions to advance the development of CAR T and CRISPR/Cas9-enhanced CAR T therapies across multiple cancers, as well as a lentiviral gene therapy for X­SCID. Mustang is registered under the Securities Exchange Act of 1934, as amended, and files periodic reports with the U.S. Securities and Exchange Commission. Mustang was founded by Fortress Biotech, Inc. (FBIO). For more information, visit www.mustangbio.com.” data-reactid=”26″>About Mustang Bio
Mustang Bio, Inc. is a clinical-stage biopharmaceutical company focused on translating today’s medical breakthroughs in cell and gene therapies into potential cures for hematologic cancers, solid tumors and rare genetic diseases. Mustang aims to acquire rights to these technologies by licensing or otherwise acquiring an ownership interest, to fund research and development, and to out license or bring the technologies to market. Mustang has partnered with top medical institutions to advance the development of CAR T and CRISPR/Cas9-enhanced CAR T therapies across multiple cancers, as well as a lentiviral gene therapy for X­SCID. Mustang is registered under the Securities Exchange Act of 1934, as amended, and files periodic reports with the U.S. Securities and Exchange Commission. Mustang was founded by Fortress Biotech, Inc. (FBIO). For more information, visit www.mustangbio.com.

<p class="canvas-atom canvas-text Mb(1.0em) Mb(0)–sm Mt(0.8em)–sm" type="text" content="About St. Jude Children’s Research Hospital
St. Jude Children’s Research Hospital is leading the way the world understands, treats and cures childhood cancer and other life-threatening diseases. It is the only National Cancer Institute-designated Comprehensive Cancer Center devoted solely to children. Treatments developed at St. Jude have helped push the overall childhood cancer survival rate from 20% to 80% since the hospital opened more than 50 years ago. St. Jude freely shares the breakthroughs it makes, and every child saved at St. Jude means doctors and scientists worldwide can use that knowledge to save thousands more children. Families never receive a bill from St. Jude for treatment, travel, housing and food — because all a family should worry about is helping their child live. To learn more, visit www.stjude.org or follow St. Jude on social media at @stjuderesearch.” data-reactid=”27″>About St. Jude Children’s Research Hospital
St. Jude Children’s Research Hospital is leading the way the world understands, treats and cures childhood cancer and other life-threatening diseases. It is the only National Cancer Institute-designated Comprehensive Cancer Center devoted solely to children. Treatments developed at St. Jude have helped push the overall childhood cancer survival rate from 20% to 80% since the hospital opened more than 50 years ago. St. Jude freely shares the breakthroughs it makes, and every child saved at St. Jude means doctors and scientists worldwide can use that knowledge to save thousands more children. Families never receive a bill from St. Jude for treatment, travel, housing and food — because all a family should worry about is helping their child live. To learn more, visit www.stjude.org or follow St. Jude on social media at @stjuderesearch.

<p class="canvas-atom canvas-text Mb(1.0em) Mb(0)–sm Mt(0.8em)–sm" type="text" content="Forward‐Looking Statements
This press release may contain “forward-looking statements” within the meaning of Section 27A of the Securities Act of 1933 and Section 21E of the Securities Exchange Act of 1934, each as amended. Such statements include, but are not limited to, any statements relating to our growth strategy and product development programs and any other statements that are not historical facts. Forward-looking statements are based on management’s current expectations and are subject to risks and uncertainties that could negatively affect Mustang Bio’s business, operating results, financial condition and stock value. Factors that could cause actual results to differ materially from those currently anticipated include: risks relating to our growth strategy; our ability to obtain, perform under and maintain financing and strategic agreements and relationships; risks relating to the results of research and development activities; risks relating to the timing of starting and completing clinical trials; uncertainties relating to preclinical and clinical testing; our dependence on third-party suppliers; our ability to attract, integrate and retain key personnel; the early stage of products under development; our need for substantial additional funds; government regulation; patent and intellectual property matters; competition; as well as other risks described in our SEC filings. We expressly disclaim any obligation or undertaking to release publicly any updates or revisions to any forward-looking statements contained herein to reflect any change in our expectations or any changes in events, conditions or circumstances on which any such statement is based, except as required by law.” data-reactid=”28″>Forward‐Looking Statements
This press release may contain “forward-looking statements” within the meaning of Section 27A of the Securities Act of 1933 and Section 21E of the Securities Exchange Act of 1934, each as amended. Such statements include, but are not limited to, any statements relating to our growth strategy and product development programs and any other statements that are not historical facts. Forward-looking statements are based on management’s current expectations and are subject to risks and uncertainties that could negatively affect Mustang Bio’s business, operating results, financial condition and stock value. Factors that could cause actual results to differ materially from those currently anticipated include: risks relating to our growth strategy; our ability to obtain, perform under and maintain financing and strategic agreements and relationships; risks relating to the results of research and development activities; risks relating to the timing of starting and completing clinical trials; uncertainties relating to preclinical and clinical testing; our dependence on third-party suppliers; our ability to attract, integrate and retain key personnel; the early stage of products under development; our need for substantial additional funds; government regulation; patent and intellectual property matters; competition; as well as other risks described in our SEC filings. We expressly disclaim any obligation or undertaking to release publicly any updates or revisions to any forward-looking statements contained herein to reflect any change in our expectations or any changes in events, conditions or circumstances on which any such statement is based, except as required by law.

<p class="canvas-atom canvas-text Mb(1.0em) Mb(0)–sm Mt(0.8em)–sm" type="text" content="Company Contacts:
Jaclyn Jaffe and William Begien
Mustang Bio, Inc.
(781) 652-4500
ir@mustangbio.com” data-reactid=”29″>Company Contacts:
Jaclyn Jaffe and William Begien
Mustang Bio, Inc.
(781) 652-4500
ir@mustangbio.com

<p class="canvas-atom canvas-text Mb(1.0em) Mb(0)–sm Mt(0.8em)–sm" type="text" content="Investor Relations Contact:
Daniel Ferry
LifeSci Advisors, LLC
(617) 535-7746
daniel@lifesciadvisors.com” data-reactid=”30″>Investor Relations Contact:
Daniel Ferry
LifeSci Advisors, LLC
(617) 535-7746
daniel@lifesciadvisors.com

<p class="canvas-atom canvas-text Mb(1.0em) Mb(0)–sm Mt(0.8em)–sm" type="text" content="Media Relations Contact:
Tony Plohoros
6 Degrees
(908) 940-0135
tplohoros@6degreespr.com &nbsp;” data-reactid=”31″>Media Relations Contact:
Tony Plohoros
6 Degrees
(908) 940-0135
tplohoros@6degreespr.com  

<p class="canvas-atom canvas-text Mb(1.0em) Mb(0)–sm Mt(0.8em)–sm" type="text" content="St. Jude Media Relations Contacts:
Marvin Stockwell
Desk: (901) 595-6384
Cell: (901) 734-8766
marvin.stockwell@stjude.org
media@stjude.org” data-reactid=”32″>St. Jude Media Relations Contacts:
Marvin Stockwell
Desk: (901) 595-6384
Cell: (901) 734-8766
marvin.stockwell@stjude.org
media@stjude.org

<p class="canvas-atom canvas-text Mb(1.0em) Mb(0)–sm Mt(0.8em)–sm" type="text" content="Michael Sheffield
Desk: (901) 595-0221
Cell: (901) 275-9065
michael.sheffield@stjude.org
media@stjude.org” data-reactid=”33″>Michael Sheffield
Desk: (901) 595-0221
Cell: (901) 275-9065
michael.sheffield@stjude.org
media@stjude.org

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.gnwunderlinestyle text-decoration: underline !important; .gnwtextalignleft text-align: left !important; .gnw_ol position: relative !important; left: 10px !important; .gnw_ul position: relative !important; left: 10px !important; .gnw_table_border_collapse td font-size: 12px !important; line-height: 1.25em !important; .gnw_border_top_solid border-top: solid black 1px !important; .gnw_border_right_solid border-right: solid black 1px !important; .gnw_border_bottom_solid border-bottom: solid black 1px !important; .gnw_border_left_solid border-left: solid black 1px !important; .gnw_border_top_double border-top: double black 3px !important; .gnw_border_right_double border-right: double black 3px !important; .gnw_border_bottom_double border-bottom: double black 3px !important; .gnw_border_left_double border-left: double black 3px !important; .gnw_table_border_collapse border-collapse: collapse !important; .gnw_align_left text-align: left !important; .gnw_align_center text-align: center !important; .gnw_align_right text-align: right !important; .gnw_align_justify text-align: justify !important; .gnw_vertical_align_top vertical-align: top !important; .gnw_vertical_align_middle vertical-align: middle !important; .gnw_vertical_align_bottom vertical-align: bottom !important; .gnw_padding_left_none padding-left: 0 !important; .gnw_padding_right_none padding-right: 0 !important; .gnw_table_border_collapse td.gnw_align_left padding-left: 0 !important;padding-right: 3px !important; .gnw_table_border_collapse td.gnw_align_right padding-left: 3px !important;padding-right: 0 !important; .gnw_heading font: 16px Arial; text-align: center !important; .gnw_subhead font: 12px Arial; text-align: center !important; .gnw_colhead font: 12px Arial; text-align: center !important; .gnw_colhead_uline font: 12px Arial; text-align: center !important; border-bottom: solid black 1.0pt; .gnw_colhead_dline font: 12px Arial; text-align: center !important; border-bottom: double black 2.5pt; .gnw_label font: 12px Arial; vertical-align: bottom !important; text-align: left !important; .gnw_label_uline font: 12px Arial; vertical-align: bottom !important; text-align: left !important; border-bottom: solid black 1.0pt; .gnw_label_uline_i10 font: 12px Arial; vertical-align: bottom !important; text-align: left !important; border-bottom: solid black 1.0pt; padding-left: 10.0px; .gnw_label_uline_i15 font: 12px Arial; vertical-align: bottom !important; text-align: left !important; border-bottom: solid black 1.0pt; padding-left: 15.0px; .gnw_label_uline_i20 font: 12px Arial; vertical-align: bottom !important; text-align: left !important; border-bottom: solid black 1.0pt; padding-left: 20.0px; .gnw_label_uline_i25 font: 12px Arial; vertical-align: bottom !important; text-align: left !important; border-bottom: solid black 1.0pt; padding-left: 25.0px; .gnw_label_uline_i30 font: 12px Arial; vertical-align: bottom !important; text-align: left !important; border-bottom: solid black 1.0pt; padding-left: 30.0px; .gnw_label_dline_i10 font: 12px Arial; vertical-align: bottom !important; text-align: left !important; border-bottom: double black 2.5pt; padding-left: 10.0px; .gnw_label_dline_i15 font: 12px Arial; vertical-align: bottom !important; text-align: left !important; border-bottom: double black 2.5pt; padding-left: 15.0px; .gnw_label_dline_i20 font: 12px Arial; vertical-align: bottom !important; text-align: left !important; border-bottom: double black 2.5pt; padding-left: 20.0px; .gnw_label_dline_i25 font: 12px Arial; vertical-align: bottom !important; text-align: left !important; border-bottom: double black 2.5pt; padding-left: 25.0px; .gnw_label_dline_i30 font: 12px Arial; vertical-align: bottom !important; text-align: left !important; border-bottom: double black 2.5pt; padding-left: 30.0px; .gnw_label_ulinetop font: 12px Arial; vertical-align: bottom !important; text-align: left !important; border-top: solid black 1.0pt; .gnw_label_dline font: 12px Arial; vertical-align: bottom !important; text-align: left !important; border-bottom: double black 2.5pt; .gnw_label_i10 font: 12px Arial; vertical-align: bottom !important; text-align: left !important; padding-left: 10.0px; .gnw_label_i15 font: 12px Arial; vertical-align: bottom !important; text-align: left !important; padding-left: 15.0px; .gnw_label_i20 font: 12px Arial; vertical-align: bottom !important; text-align: left !important; padding-left: 20.0px; .gnw_label_i25 font: 12px Arial; vertical-align: bottom !important; text-align: left !important; padding-left: 25.0px; .gnw_label_i30 font: 12px Arial; vertical-align: bottom !important; text-align: left !important; padding-left: 30.0px; .gnw_num font: 12px Arial; vertical-align: bottom !important; text-align: right !important; white-space: nowrap !important; .gnw_num_uline font: 12px Arial; vertical-align: bottom !important; text-align: right !important; white-space: nowrap !important; border-bottom: solid black 1.0pt; .gnw_num_ulinetop font: 12px Arial; vertical-align: bottom !important; text-align: right !important; white-space: nowrap !important; border-top: solid black 1.0pt; .gnw_num_dline font: 12px Arial; vertical-align: bottom !important; text-align: right !important; white-space: nowrap !important; border-bottom: double black 2.5pt; .gnw_num_dlinetop font: 12px Arial; vertical-align: bottom !important; text-align: right !important; white-space: nowrap !important; border-top: double black 2.5pt; .gnw_data font: 12px Arial; vertical-align: bottom !important; text-align: left !important; white-space: nowrap !important; .gnw_data_uline font: 12px Arial; vertical-align: bottom !important; text-align: left !important; border-bottom: solid black 1.0pt; .gnw_data_dline font: 12px Arial; vertical-align: bottom !important; text-align: left !important; border-bottom: double black 2.5pt; .gnw_news_media_box margin-top: 15px !important; margin-left: 6px !important; margin-bottom: 6px !important; margin-right: 6px !important; border-width: 1px !important; border-color: #A9A9A9 !important; border-style: solid !important; .gnw_media_caption font-size: 8pt !important; font-family: Verdana, Arial, Helvetica, Geneva, Swiss, SunSans-Regular !important; .gnw_media_bgcolor background-color: transparent !important; .gnw_table border-collapse: separate !important; border-spacing: 6px !important; .gnw_videotitle font: bold 12px Arial !important; color: #1d5296 !important; td.gnw_heading font: 16px Arial; text-align: center !important; td.gnw_subhead font: 12px Arial; text-align: center !important; td.gnw_colhead font: 12px Arial; text-align: center !important; td.gnw_colhead_uline font: 12px Arial; text-align: center !important; border-bottom: solid black 1.0pt; td.gnw_colhead_dline font: 12px Arial; text-align: center !important; border-bottom: double black 2.5pt; td.gnw_label font: 12px Arial; vertical-align: bottom !important; text-align: left !important; td.gnw_label_uline font: 12px Arial; vertical-align: bottom !important; text-align: left !important; border-bottom: solid black 1.0pt; td.gnw_label_uline_i10 font: 12px Arial; vertical-align: bottom !important; text-align: left !important; border-bottom: solid black 1.0pt; padding-left: 10.0px; td.gnw_label_uline_i15 font: 12px Arial; vertical-align: bottom !important; text-align: left !important; border-bottom: solid black 1.0pt; padding-left: 15.0px; td.gnw_label_uline_i20 font: 12px Arial; vertical-align: bottom !important; text-align: left !important; border-bottom: solid black 1.0pt; padding-left: 20.0px; td.gnw_label_uline_i25 font: 12px Arial; vertical-align: bottom !important; text-align: left !important; border-bottom: solid black 1.0pt; padding-left: 25.0px; td.gnw_label_uline_i30 font: 12px Arial; vertical-align: bottom !important; text-align: left !important; border-bottom: solid black 1.0pt; padding-left: 30.0px; td.gnw_label_dline_i10 font: 12px Arial; vertical-align: bottom !important; text-align: left !important; border-bottom: double black 2.5pt; padding-left: 10.0px; td.gnw_label_dline_i15 font: 12px Arial; vertical-align: bottom !important; text-align: left !important; border-bottom: double black 2.5pt; padding-left: 15.0px; td.gnw_label_dline_i20 font: 12px Arial; vertical-align: bottom !important; text-align: left !important; border-bottom: double black 2.5pt; padding-left: 20.0px; td.gnw_label_dline_i25 font: 12px Arial; vertical-align: bottom !important; text-align: left !important; border-bottom: double black 2.5pt; padding-left: 25.0px; td.gnw_label_dline_i30 font: 12px Arial; vertical-align: bottom !important; text-align: left !important; border-bottom: double black 2.5pt; padding-left: 30.0px; td.gnw_label_ulinetop font: 12px Arial; vertical-align: bottom !important; text-align: left !important; border-top: solid black 1.0pt; td.gnw_label_dline font: 12px Arial; vertical-align: bottom !important; text-align: left !important; border-bottom: double black 2.5pt; td.gnw_label_i10 font: 12px Arial; vertical-align: bottom !important; text-align: left !important; padding-left: 10.0px; td.gnw_label_i15 font: 12px Arial; vertical-align: bottom !important; text-align: left !important; padding-left: 15.0px; td.gnw_label_i20 font: 12px Arial; vertical-align: bottom !important; text-align: left !important; padding-left: 20.0px; td.gnw_label_i25 font: 12px Arial; vertical-align: bottom !important; text-align: left !important; padding-left: 25.0px; td.gnw_label_i30 font: 12px Arial; vertical-align: bottom !important; text-align: left !important; padding-left: 30.0px; td.gnw_num font: 12px Arial; vertical-align: bottom !important; text-align: right !important; white-space: nowrap !important; td.gnw_num_uline font: 12px Arial; vertical-align: bottom !important; text-align: right !important; white-space: nowrap !important; border-bottom: solid black 1.0pt; td.gnw_num_ulinetop font: 12px Arial; vertical-align: bottom !important; text-align: right !important; white-space: nowrap !important; border-top: solid black 1.0pt; td.gnw_num_dline font: 12px Arial; vertical-align: bottom !important; text-align: right !important; white-space: nowrap !important; border-bottom: double black 2.5pt; td.gnw_num_dlinetop font: 12px Arial; vertical-align: bottom !important; text-align: right !important; white-space: nowrap !important; border-top: double black 2.5pt; td.gnw_data font: 12px Arial; vertical-align: bottom !important; text-align: left !important; white-space: nowrap !important; td.gnw_data_uline font: 12px Arial; vertical-align: bottom !important; text-align: left !important; border-bottom: solid black 1.0pt; td.gnw_data_dline font: 12px Arial; vertical-align: bottom !important; text-align: left !important; border-bottom: double black 2.5pt; td.gnw_media_caption font-size: 8pt !important; font-family: Verdana, Arial, Helvetica, Geneva, Swiss, SunSans-Regular !important; td.gnw_videotitle font: bold 12px Arial !important; color: #1d5296 !important; ;}

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